PROTAC ER Degrader-4 |
| رقم الكتالوجGC64350 |
PROTAC ER Degrader-4 عبارة عن مطهر PROATC لمستقبلات هرمون الاستروجين (ER) القائم على فون هيبل لينداو ، وهو مرتبط بـ ER مع IC 50 من 0.8 نانومتريحفز PROTAC ER Degrader-4 تدهور ER في خلايا MCF-7 مع IC50 من 0.3 نانومتر
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Cas No.: 2361114-15-8
Sample solution is provided at 25 µL, 10mM.
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PROTAC ER Degrader-4 is a von Hippel-Lindau-based PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1].
PROTAC ER Degrader-4 shows equal to 100% ER degradation at 0.3 μM in the MCF-7 ER degradation cellular assay[1].
[1]. Bin Yang, et al. Compounds and their use in treating cancer. WO2019123367A1.
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