PROTAC RIPK degrader-6 |
| رقم الكتالوجGC61215 |
PROTAC RIPK degrader-6 (المثال 1) عبارة عن PROTAC قائم على Cereblon يستهدف تدهور RIP Kinase حيث يتم ربط مثبط كيناز RIP2 عبر رابط إلى رابط cereblon
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Cas No.: 2089205-64-9
Sample solution is provided at 25 µL, 10mM.
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PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder[1].
PROTACs is useful for the targeted degradation of proteins and other polypeptides which on the one end binds to the cereblon and on the other end to the target protein (RIP2 kinase). By bringing the target protein in close proximity to the E3-Ligase, these compounds form a ternary complex leading to polyubiquitination of the target protein inducing its degradation[1].
[1]. John David Harlin, et al. Compounds for the modulation of rip2 kinase activity. WO2017046036A1.
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