Radioprotectin-1 |
| رقم الكتالوجGC34752 |
Radioprotectin-1 هو ناهض غير دهني قوي ومحدد لمستقبلات حمض الليزوفوسفاتيدك 2 (LPA2) ، بقيمة EC50 تبلغ 25 نانومتر للنوع الفرعي LPA2 الفئران
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1622006-09-0
Sample solution is provided at 25 µL, 10mM.
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Radioprotectin-1 is a potent and specific nonlipid agonist of LPA2, with an EC50 value of 25 nM for murine LPA2 subtype[1]. EC50: 25 nM (murine LPA2 subtype)[1]
Radioprotectin-1 is a potent agonist of LPA2 with an EC50 of 5 pM and functions as a full agonist at the human ortholog of LPA2[1].Radioprotectin-1 (0-3 μM; 15 minutes) effectively reduces apoptosis induced by γ-irradiation and the radiomimetic drug Adriamycin in cells that expressed LPA2 either endogenously or after transfection[1]. Cell Viability Assay[1] Cell Line: MEF cells , IEC-6 cells
Radioprotectin-1 is a high-potency specific agonist of the murine LPA2 GPCR [1].Radioprotectin-1 (0.1 mg/kg, 0.3 mg/kg; s.c.; every 12 hours; for 3 days) decreases the mortality of C57BL/6 mice in models of the hematopoietic acute radiation syndromes (HE-ARS) and gastrointestinal acute radiation syndromes (GI-ARS) [1].Radioprotectin-1 exerts its radioprotective and radiomitigative action through specific activation of the upregulated LPA2 GPCR in Lgr5+stem cells[1]. Animal Model: 8-10 weeks old C57BL/6 female mice bearing total body irradiation (TBI) [1]
[1]. Kuo B, et al. The LPA2 receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids. Cell Signal. 2018 Nov;51:23-33.
| Cas No. | 1622006-09-0 | SDF | |
| Canonical SMILES | O=C(O)C1=CC(Cl)=CC=C1S(=O)(NCCCCN(C(C2=CC=CC3=CC=CC4=C23)=O)C4=O)=O | ||
| Formula | C23H19ClN2O6S | M.Wt | 486.92 |
| الذوبان | DMSO : 125 mg/mL (256.72 mM);Water : < 0.1 mg/mL (insoluble) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0537 mL | 10.2686 mL | 20.5373 mL |
| 5 mM | 0.4107 mL | 2.0537 mL | 4.1075 mL |
| 10 mM | 0.2054 mL | 1.0269 mL | 2.0537 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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