Radioprotectin-1 |
カタログ番号GC34752 |
Radioprotectin-1 は、リゾホスファチジン酸受容体 2 (LPA2) の強力で特異的な非脂質アゴニストであり、マウス LPA2 サブタイプの EC50 値は 25 nM です 。
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Cas No.: 1622006-09-0
Sample solution is provided at 25 µL, 10mM.
Radioprotectin-1 is a potent and specific nonlipid agonist of LPA2, with an EC50 value of 25 nM for murine LPA2 subtype[1]. EC50: 25 nM (murine LPA2 subtype)[1]
Radioprotectin-1 is a potent agonist of LPA2 with an EC50 of 5 pM and functions as a full agonist at the human ortholog of LPA2[1].Radioprotectin-1 (0-3 μM; 15 minutes) effectively reduces apoptosis induced by γ-irradiation and the radiomimetic drug Adriamycin in cells that expressed LPA2 either endogenously or after transfection[1]. Cell Viability Assay[1] Cell Line: MEF cells , IEC-6 cells
Radioprotectin-1 is a high-potency specific agonist of the murine LPA2 GPCR [1].Radioprotectin-1 (0.1 mg/kg, 0.3 mg/kg; s.c.; every 12 hours; for 3 days) decreases the mortality of C57BL/6 mice in models of the hematopoietic acute radiation syndromes (HE-ARS) and gastrointestinal acute radiation syndromes (GI-ARS) [1].Radioprotectin-1 exerts its radioprotective and radiomitigative action through specific activation of the upregulated LPA2 GPCR in Lgr5+stem cells[1]. Animal Model: 8-10 weeks old C57BL/6 female mice bearing total body irradiation (TBI) [1]
[1]. Kuo B, et al. The LPA2 receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids. Cell Signal. 2018 Nov;51:23-33.
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