E3 ligase Ligand 9 |
| رقم الكتالوجGC34566 |
E3 ligase Ligand 9 عبارة عن يجند لـ E3 ubiquitin ligaseيمكن توصيل E3 ligase Ligand 9 بالرابط الخاص بالبروتين عن طريق رابط لتكوين PROTACs أو SNIPERsPROTACs هي محرضات على تحلل البروتينات المعززة للسرطان بوساطة الانتشار
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2093388-45-3
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 9 is a Ligand of BETd-260 for E3 Ligase used in PROTAC. BETd-260 is a potent BET degrader based on PROTAC technology, with an IC50 of 51 pM against BRD4 protein in RS4;11 leukemia cell line[1]. E3 ligase[1].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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