E3 ligase Ligand 9 |
| Catalog No.GC34566 |
E3 ligase Ligand 9 est un ligand de l'ubiquitine ligase E3. Le ligand 9 de la ligase E3 peut être connecté au ligand de la protéine par un lieur pour former des PROTAC ou des SNIPER. Les PROTAC sont des inducteurs de la dégradation médiée par l'ubiquitination des protéines favorisant le cancer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2093388-45-3
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 9 is a Ligand of BETd-260 for E3 Ligase used in PROTAC. BETd-260 is a potent BET degrader based on PROTAC technology, with an IC50 of 51 pM against BRD4 protein in RS4;11 leukemia cell line[1]. E3 ligase[1].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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