E3 ligase Ligand 9 |
カタログ番号GC34566 |
E3 ligase Ligand 9 は E3 ユビキチン リガーゼのリガンドです。 E3 リガーゼ リガンド 9 は、リンカーによってタンパク質のリガンドに接続され、PROTAC または SNIPER を形成します。 PROTAC は、がん促進タンパク質のユビキチン化を介した分解のインデューサーです。
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Cas No.: 2093388-45-3
Sample solution is provided at 25 µL, 10mM.
E3 ligase Ligand 9 is a Ligand of BETd-260 for E3 Ligase used in PROTAC. BETd-260 is a potent BET degrader based on PROTAC technology, with an IC50 of 51 pM against BRD4 protein in RS4;11 leukemia cell line[1]. E3 ligase[1].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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