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Chromatin/Epigenetics

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Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Research Areas

Products Related to Chromatin/Epigenetics(1939)

  • GC43865 structure
    GC43865Histone H4 Peptide Substrate (15-24)
    Purity: >98.00%

    Histone H4 undergoes many modifications including acetylation, methylation, and phosphorylation, each important for regulation of gene transcription.

  • GC43889 structure
    GC43889I-CBP112 (hydrochloride)
    CAS: 2147701-33-3
    Purity: >90.00%

    I-CBP112 (هيدروكلوريد) هو مثبط انتقائي لـ CBP / P300 يربط مباشرة برومودومين (Kds \u003d 142 و 625 نانومتر ، على التوالي). يقلل I-CBP112 بشكل كبير من إمكانية بدء سرطان الدم لخلايا سرطان الدم النخاعي الحاد MLL-AF9 (+) بطريقة تعتمد على الجرعة في المختبر وفي الجسم الحي. يزيد I-CBP112 من النشاط السام للخلايا لمثبط BET bromodomain JQ1 وكذلك دوكسوروبيسين.

  • GC44184 structure
    GC44184Methylstat (hydrate)
    Purity: >98.00%

    Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability.

  • GC44250 structure
    GC44250MS351
    CAS: 472984-79-5
    Purity: >98.00%

    MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain.

  • GC44401 structure
    GC44401Nicotinamide riboside
    CAS: 1341-23-7
    Purity: >99.50%

    يتم تحويل النيكوتيناميد رايبوسايد، وهو شكل من أشكال فيتامين ب3 ومادة مسبقة لـ NAD+، إلى NAD+ المتاح حيوية عبر نزع فسفات من قِبَل إنزيم NRK (nicotinamide riboside kinase) و NMNAT، أو عبر عملية الإضافة التأرجحية لفسفات النُّكْلِئُوزِ وإعادة استخدام NAM.

  • GC44477 structure
    GC44477NVS-CECR2-1
    CAS: 1992047-61-6
    Purity: >99.00%

    NVS-CECR2-1 ، مثبط Bromodomain (BRD) من غير عائلة BET ، هو منطقة كروموسوم لمتلازمة عين القط انتقائية وقوية ، ومثبط مرشح 2 (CECR2)يرتبط NVS-CECR2-1 بـ CECR2 BRD بتقارب عالٍ (IC50 = 47 نانومتر ؛ دينار كويتي = 80 نانومتر)يُظهر NVS-CECR2-1 نشاطًا سامًا للخلايا ويحث على موت الخلايا المبرمج ضد الخلايا السرطانية المختلفة عن طريق استهداف CECR2 وكذلك عبر آلية مستقلة عن CECR2

  • GC44668 structure
    GC44668Posaconazole D-Glucuronide
    Purity: >80.00%

    Posaconazole D-glucuronide is a metabolite of the antifungal agent posaconazole.

  • GC44859 structure
    GC44859S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)
    CAS: 86867-01-8
    Purity: >95.00%

    S-(5'-Adenosyl)-L-methionine chloride (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases.

  • GC44865 structure
    GC44865SAHA-BPyne
    CAS: 930772-88-6
    Purity: >98.00%

    Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.

  • GC44866 structure
    GC44866SAHA-d5
    CAS: 1132749-48-4
    Purity: >99.00%

    SAHA-d5 (SAHA-d5) هو الديوتيريوم المسمى Vorinostat.

  • GC44886 structure
    GC44886S-Farnesyl Thioacetic Acid
    CAS: 135784-48-4
    Purity: >97.00%

    S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine which behaves as a competitive inhibitor of isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase).

  • GC44984 structure
    GC44984TAF 10 Peptide
    Purity: >98.00%

    TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity.

  • GC45005 structure
    GC45005TDFA (trifluoroacetate salt)
    Purity: >98.00%
  • GC45029 structure
    GC45029TFMB-R-2-HG
    CAS: 1445700-01-5
    Purity: >98.00%

    TFMB-R-2-HG is a cell-permeable form of (R)-2-hydroxyglutarate ((R)-2-HG).

  • GC45080 structure
    GC45080Trichostatin C
    CAS: 68676-88-0
    Purity: >95.00%

    Trichostatin C is a glycosylated derivative of trichostatin A, the antifungal antibiotic that reversibly inhibits histone deacetylase.

  • GC45094 structure
    GC45094TTK21
    CAS: 709676-56-2
    Purity: >98.00%

    TTK21 هو منشط للهيستون أسيتيل ترانسفيرازات CBP / p300

  • GC45095 structure
    GC45095Tubastatin A (trifluoroacetate salt)
    CAS: 1239262-52-2
    Purity: >95.00%

    Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.

  • GC45116 structure
    GC45116UNC2170 (maleate)
    CAS: 2173992-60-2
    Purity: >95.00%

    p53-Binding protein 1 (53BP1) binds to dimethylated lysine 20 on histone 4 (H4K20me2) via tandem tudor domains on a 53BP1 homodimer.

  • GC45117 structure
    GC45117UNC2327
    CAS: 1426152-53-5
    Purity: >98.00%

    UNC2327 هو مثبط خيفي من بروتين أرجينين ميثيل ترانسفيراز 3 (PRMT3)

  • GC45137 structure
    GC45137Valproic Acid Acyl-D-Glucuronide
    Purity: >95.00%

    Valproic acid acyl-D-glucuronide is the major urinary metabolite of valproic acid.

  • GC45258 structure
    GC45258(+)-Biotin 4-Amidobenzoic Acid (sodium salt)
    CAS: 102418-74-6
    Purity: >98.00%

    (+)-Biotin 4-amidobenzoic acid is a substrate of biotinidase, which cleaves biotin amide to give biotin in vivo.

  • GC45389 structure
    GC45389BAY-6035
    CAS: 2247890-13-5
    Purity: >95.00%

    يعتبر BAY-6035 مثبطًا قويًا وانتقائيًا وتنافسيًا للركيزة لـ SMYD3BAY-6035 يمنع مثيلة ببتيد MEKK2 مع IC50 من 88 نانومتر

  • GC45402 structure
    GC45402CAY10729 (trifluoroacetate salt) (technical grade)
    Purity: >70.00%

  • GC45474 structure
    GC45474Histone H3 (1-25) amide (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
    Purity: >95.00%