Retro-2 (Synonyms: RN 1-001) |
| رقم الكتالوجGC18485 |
Retro-2 (RN 1-001) هو مثبط ثنائي هيدروكينازولينون (DHQZ) للإتجار الرجعي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1429192-00-6
Sample solution is provided at 25 µL, 10mM.
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Retro-2 is a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface between the endosome and trans-Golgi network, with no discernable effects on other intracellular trafficking pathways. Retro-2 inhibits ebolavirus infection with an EC50 value of 12.2 uM and reduces ricin-induced toxicity by 2.7-fold when used at a concentration of 20 uM in HeLa cells. Retro-2 also blocks JC polyomavirus, BK polyomavirus, and SV40 infectivity in Vero green monkey kidney epithelial cells in vitro (EC50s = 28.4, 61.2, and 58.6 uM, respectively). In mouse models, Retro-2 improves survival and reduces symptoms following infection with Shiga toxin-producing E. coli when administered at a dose of 100 mg/kg and protects against ricin challenge when administered prophylactically at a dose of 2 mg/kg.
Review for Retro-2
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
Review for Retro-2
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