الصفحة الرئيسية>>Signaling Pathways>> Microbiology & Virology>> Arenavirus>>Retro-2

Retro-2 (Synonyms: RN 1-001)

رقم الكتالوجGC18485

Retro-2 (RN 1-001) هو مثبط ثنائي هيدروكينازولينون (DHQZ) للإتجار الرجعي.

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Retro-2 التركيب الكيميائي

Cas No.: 1429192-00-6

الحجم السعر المخزون الكميّة
10mM 1 mL in DMSO
84٫00
متوفر
5mg
77٫00
متوفر
10mg
126٫00
متوفر
50mg
378٫00
متوفر
100mg
612٫00
متوفر

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مراجعات العميل

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  • GlpBio Citations

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Sample solution is provided at 25 µL, 10mM.

Description of Retro-2

Retro-2 is a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface between the endosome and trans-Golgi network, with no discernable effects on other intracellular trafficking pathways. Retro-2 inhibits ebolavirus infection with an EC50 value of 12.2 uM and reduces ricin-induced toxicity by 2.7-fold when used at a concentration of 20 uM in HeLa cells. Retro-2 also blocks JC polyomavirus, BK polyomavirus, and SV40 infectivity in Vero green monkey kidney epithelial cells in vitro (EC50s = 28.4, 61.2, and 58.6 uM, respectively). In mouse models, Retro-2 improves survival and reduces symptoms following infection with Shiga toxin-producing E. coli when administered at a dose of 100 mg/kg and protects against ricin challenge when administered prophylactically at a dose of 2 mg/kg.

Chemical Properties of Retro-2

Cas No. 1429192-00-6 SDF
المرادفات RN 1-001
Chemical Name 2,3-dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone
Canonical SMILES O=C1C2=CC=CC=C2NC(C3=CC=C(C)S3)N1C4=CC=CC=C4
Formula C19H16N2OS M.Wt 320.4
الذوبان DMSO : ≥ 125 mg/mL (390.13 mM);Water : < 0.1 mg/mL (insoluble) Storage Store at -20°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Retro-2

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.1211 mL 15.6055 mL 31.211 mL
5 mM 0.6242 mL 3.1211 mL 6.2422 mL
10 mM 0.3121 mL 1.5605 mL 3.1211 mL
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In vivo Formulation Calculator (Clear solution) of Retro-2

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Average Rating: 5 ★★★★★ (Based on Reviews and 16 reference(s) in Google Scholar.)

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