RIP2 kinase inhibitor 2 |
| رقم الكتالوجGC32860 |
مثبط RIP2 كيناز 2 هو مثبط كيناز متفاعل للبروتين -2 (RIP2) مستخرج من براءة اختراع WO / 2014043437 A1 ، مثال مركب 9
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Cas No.: 1581270-11-2
Sample solution is provided at 25 µL, 10mM.
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RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9.
RIP2 kinase inhibitor 2 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase is a TKL family serine/threonine protein kinase involved in innate immune signaling. Following activation, RIP2 kinase associates with NODI or NOD2 and appears to function principally as a molecular scaffold to bring together other kinases (TAK1, Ικκα/β/γ) involved in NF-κβ and mitogen-activated protein kinase activation[1].
[1]. Linda N. Casillas, et al. Amino-quinolines as kinase inhibitors. PCT Int. Appl. (2014), WO 2014043437 A1 20140320.
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