Seltorexant hydrochloride (Synonyms: JNJ-42847922 hydrochloride) |
| رقم الكتالوجGC61273 |
هيدروكلوريد Seltorexant (JNJ-42847922 hydrochloride) هو مضاد OX2R نشط عن طريق الفم وذو تقارب عالي وانتقائي (قيم pKi تبلغ 8.0 و 8.1 للإنسان والجرذان OX2R)
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Cas No.: 1293284-49-7
Sample solution is provided at 25 µL, 10mM.
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Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1].
Seltorexant hydrochloride (JNJ-42847922 hydrochloride) (3-30 mg/kg; p.o.) dose-dependently induces and prolongs sleep in male Sprague-Dawley rats[1].The sleep-promoting effects of Seltorexant hydrochloride (30 mg/kg; p.o.; per day for 7 days) are maintained upon 7-day repeated dosing in rats[1]. Animal Model: Male Sprague-Dawley rats (350-450 g)[1]
[1]. Bonaventure P, et al. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia. J Pharmacol Exp Ther. 2015 Sep;354(3):471-82.
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