Seltorexant hydrochloride (Synonyms: JNJ-42847922 hydrochloride) |
| Catalog No.GC61273 |
셀토렉산트 염산염(JNJ-42847922 염산염)은 경구 활성, 고친화성 및 선택적 OX2R 길항제입니다(인간 및 쥐 OX2R의 경우 pKi 값 8.0 및 8.1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1293284-49-7
Sample solution is provided at 25 µL, 10mM.
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Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1].
Seltorexant hydrochloride (JNJ-42847922 hydrochloride) (3-30 mg/kg; p.o.) dose-dependently induces and prolongs sleep in male Sprague-Dawley rats[1].The sleep-promoting effects of Seltorexant hydrochloride (30 mg/kg; p.o.; per day for 7 days) are maintained upon 7-day repeated dosing in rats[1]. Animal Model: Male Sprague-Dawley rats (350-450 g)[1]
[1]. Bonaventure P, et al. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia. J Pharmacol Exp Ther. 2015 Sep;354(3):471-82.
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