SGC-iMLLT |
| رقم الكتالوجGC34778 |
SGC-iMLLT هو أول مسبار كيميائي في فئته ومثبط انتقائي قوي لتفاعلات MLLT1 / 3-هيستون مع IC 50 من 0.26 ميكرومتريُظهر SGC-iMLLT نشاطًا عاليًا للربط تجاه مجال MLLT1 YEATS (YD) و MLLT3 YD (AF9 / YEATS3) مع Kds من 0.129 و 0.077 ميكرومتر ، على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2255338-25-9
Sample solution is provided at 25 µL, 10mM.
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SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interactions, occupies the Kac/Kcr binding site of MLLT1 YD (ENL/YEATS1), with high binding activity at MLLT1 YD (IC50, 0.26 μM; Kd, 0.129 μM) and MLLT3 YD (AF9/YEATS3) (Kd, 0.077 μM)[1]. IC50: 0.26 μM (MLLT1 YD)[1]Kd: 0.077 μM (MLLT3 YD), 0.129 μM (MLLT1 YD)[1]
[1]. Moustakim M, et al. Discovery of an MLLT1/3 YEATS Domain Chemical Probe. Angew Chem Int Ed Engl. 2018 Dec 10;57(50):16302-16307.
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