SID 3712249 (MiR-544 Inhibitor 1) (Synonyms: MiR-544 Inhibitor 1) |
| رقم الكتالوجGC32973 |
SID 3712249 (MiR-544 Inhibitor 1) (MiR-544 Inhibitor 1) هو مثبط للتكوين الحيوي miR-544. يرتبط SID 3712249 (MiR-544 Inhibitor 1) مباشرة بالسلائف miRNA. يمنع SID 3712249 (MiR-544 Inhibitor 1) إنتاج microRNA الناضج ويقلل miR-544 و HIF-1α ؛ ونسخ ATM. يمكن استخدام SID 3712249 (MiR-544 Inhibitor 1) في البحث عن السرطانات ، مثل سرطان الثدي.
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Cas No.: 522606-67-3
Sample solution is provided at 25 µL, 10mM.
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SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). Target: MiR-544MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.
[1]. Zhi Q, et al. Oncogenic miR-544 is an important molecular target in gastric cancer. Anticancer Agents Med Chem. 2013 Feb;13(2):270-5.
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