SID 3712249 (MiR-544 Inhibitor 1) (Synonyms: MiR-544 Inhibitor 1) |
| Catalog No.GC32973 |
SID 3712249 (MiR-544 Inhibitor 1) (MiR-544 Inhibitor 1) est un inhibiteur de la biogenèse miR-544. SID 3712249 (MiR-544 Inhibitor 1) se lie directement au miARN précurseur. SID 3712249 (MiR-544 Inhibitor 1) bloque la production du microARN mature et diminue les transcrits miR-544, HIF-1α et ATM. Le SID 3712249 (MiR-544 Inhibitor 1) peut être utilisé dans la recherche sur les cancers, comme le cancer du sein.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 522606-67-3
Sample solution is provided at 25 µL, 10mM.
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SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). Target: MiR-544MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.
[1]. Zhi Q, et al. Oncogenic miR-544 is an important molecular target in gastric cancer. Anticancer Agents Med Chem. 2013 Feb;13(2):270-5.
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