SID 3712249 (MiR-544 Inhibitor 1) (Synonyms: MiR-544 Inhibitor 1) |
| Catalog No.GC32973 |
SID 3712249(MiR-544 억제제 1)(MiR-544 억제제 1)는 miR-544 생합성 억제제입니다. SID 3712249(MiR-544 억제제 1)는 전구체 miRNA에 직접 결합합니다. SID 3712249(MiR-544 Inhibitor 1)는 성숙한 마이크로RNA의 생산을 차단하고 miR-544, HIF-1α, ATM 전사체를 감소시킵니다. SID 3712249(MiR-544 Inhibitor 1)는 유방암과 같은 암 연구에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 522606-67-3
Sample solution is provided at 25 µL, 10mM.
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SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). Target: MiR-544MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.
[1]. Zhi Q, et al. Oncogenic miR-544 is an important molecular target in gastric cancer. Anticancer Agents Med Chem. 2013 Feb;13(2):270-5.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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