SKLB-197 |
| رقم الكتالوجGC64539 |
أظهر SKLB-197 قيمة IC50 تبلغ 0.013 ميكرومتر مقابل ATR ولكن ضعيف جدًا أو لا يوجد نشاط مقابل 402 كينازات بروتين أخرىأظهر نشاطًا قويًا مضادًا للأورام ضد الأورام التي تعاني من نقص أجهزة الصراف الآلي في المختبر وفي الجسم الحي
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Cas No.: 2713577-16-1
Sample solution is provided at 25 µL, 10mM.
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SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
[1]. Bin H,et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187
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