SKLB-197 |
| Catalog No.GC64539 |
SKLB-197은 ATR에 대해 0.013μM의 IC50 값을 나타내었지만 다른 402 protein kinase에 대해서는 매우 약하거나 활성이 없었다. 시험관 내 및 생체 내에서 ATM 결핍 종양에 대해 강력한 항종양 활성을 나타냈습니다.
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Cas No.: 2713577-16-1
Sample solution is provided at 25 µL, 10mM.
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SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
[1]. Bin H,et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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