SKLB-197 |
| Catalog No.GC64539 |
SKLB-197 a montré une valeur IC50 de 0,013 μM contre l'ATR mais une activité très faible ou nulle contre les autres 402 protéines kinases. Il a montré une puissante activité antitumorale contre les tumeurs déficientes en ATM À la fois in vitro et in vivo.
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Cas No.: 2713577-16-1
Sample solution is provided at 25 µL, 10mM.
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SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
[1]. Bin H,et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187
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