Squarunkin A hydrochloride |
رقم الكتالوجGC50430 |
Squarunkin A هيدروكلوريد هو مثبط فعال وانتقائي لتفاعل البضائع UNC119 (IC50 من 10 نانومتر لتثبيط UNC119A-myristoylated Src N- تفاعل الببتيد الطرفي)يتداخل Squarunkin A هيدروكلوريد مع تنشيط Src kinase في الخلايا
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Cas No.: 2253744-55-5
Sample solution is provided at 25 µL, 10mM.
Potent inhibitor of UNC119 chaperone protein-cargo interaction (IC50 = 10 nM for inhibition of UNC119A - myristoylated Src N-terminal peptide interaction). Disrupts activation of Src kinase in vitro.
Mejuch et al (2017) Small-molecule inhibition of the UNC119-cargo interaction. Angew.Chem.Int.Ed. 56 6181 PMID:28471079
Average Rating: 5
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