الصفحة الرئيسية>>Signaling Pathways>> Cell Cycle/Checkpoint>> Microtubule/Tubulin>>Thiocolchicine

Thiocolchicine (Synonyms: NSC 186301)

رقم الكتالوجGC45039

Thiocolchicine ، مشتق معدل في الحلقة C من الكولشيسين مع خصائص بيولوجية محسنةThiocolchicine هو مثبط قوي لبلمرة التوبولين (IC50 = 2.5 ميكرومتر) ويرتبط بشكل تنافسي مع التوبولين مع كي من 0.7 ميكرومتريحفز ثيوكولشيسين موت الخلايا المبرمجيمكن استخدام Thiocolchicine كسم خلوي ADC في تقنية ADC

Products are for research use only. Not for human use. We do not sell to patients.

Thiocolchicine التركيب الكيميائي

Cas No.: 2730-71-4

الحجم السعر المخزون الكميّة
5mg
52٫00
متوفر
10mg
98٫00
متوفر
25mg
231٫00
متوفر
100mg
720٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


مراجعات العميل

بناء على آراء العملاء.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Description of Thiocolchicine

Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 µM) and a derivative of colchicine . It inhibits binding of colchicine to tubulin (Ki = 0.7 µM in a radioligand binding assay). Thiocolchicine inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM).

Chemical Properties of Thiocolchicine

Cas No. 2730-71-4 SDF
المرادفات NSC 186301
Canonical SMILES O=C1C(SC)=CC=C2C([C@@H](NC(C)=O)CCC3=C2C(OC)=C(OC)C(OC)=C3)=C1
Formula C22H25NO5S M.Wt 415.5
الذوبان DMSO: soluble,Ethanol: soluble,Methanol: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Thiocolchicine

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.4067 mL 12.0337 mL 24.0674 mL
5 mM 0.4813 mL 2.4067 mL 4.8135 mL
10 mM 0.2407 mL 1.2034 mL 2.4067 mL
  • حاسبة المولارية

  • حاسبة التخفيف

  • Molecular Weight Calculator

كتلة
=
تركيز
x
مقدار
x
ميغاواط *
 
 
 
** عند إعداد حلول المخزون، دائمًا استخدم الوزن الجزيئي الخاص بالدفعة للمنتج على ملصق القارورة MSDS / CoA (متوفر عبر الإنترنت).

احسب

In vivo Formulation Calculator (Clear solution) of Thiocolchicine

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

View current batch:

مراجعات

Review for Thiocolchicine

Average Rating: 5 ★★★★★ (Based on Reviews and 39 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for Thiocolchicine

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.