Thiocolchicine (Synonyms: NSC 186301) |
| Katalog-Nr.GC45039 |
Thiocolchicin, ein im C-Ring von Colchicin modifiziertes Derivat mit verbesserten biologischen Eigenschaften. Thiocolchicin ist ein potenter Inhibitor der Tubulinpolymerisation (IC50=2,5 μM) und bindet kompetitiv an Tubulin mit einem Ki von 0,7 μM. Thiocolchicin induziert Zellapoptose. Thiocolchicin kann als ADC-Zytotoxin in der ADC-Technologie verwendet werden.
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Cas No.: 2730-71-4
Sample solution is provided at 25 µL, 10mM.
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Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 µM) and a derivative of colchicine . It inhibits binding of colchicine to tubulin (Ki = 0.7 µM in a radioligand binding assay). Thiocolchicine inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM).
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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