Tirabrutinib (ONO-4059) (Synonyms: GS-4059, ONO-WG-307, Tirabrutinib) |
| رقم الكتالوجGC33821 |
Tirabrutinib (ONO-4059) (ONO-4059) هو مثبط نشط عن طريق الفم Bruton' ؛ s Tyrosine Kinase (BTK) (يمكنه عبور الحاجز الدموي الدماغي (BBB)) ، مع IC50 من 6.8 نانومتر.
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Cas No.: 1351636-18-4
Sample solution is provided at 25 µL, 10mM.
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Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM.
[1]. Burger JA. Bruton's tyrosine kinase (BTK) inhibitors in clinical trials. Curr Hematol Malig Rep, 2014 Mar, 9(1):44-9. [2]. Harriet S. Walter et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood, 2016 Jan 28, 127(4): 411-419.
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