TL 13-12 |
| رقم الكتالوجGC50560 |
TL 13-12 عبارة عن مطهر ALK-PROTAC قوي وانتقائي ويثبط نشاط ALK بقيمة IC50 تبلغ 0.69 نانومتر. يدفع TL 13-12 أيضًا إلى تدهور كينازات إضافية بما في ذلك Aurora A و FER و PTK2 و RPS6KA1 بقيم IC50 البالغة 13.5 نانومتر و 5.74 نانومتر و 18.4 نانومتر و 65 نانومتر ، على التوالي. يتكون TL 13-12 من اقتران TAE684 ورابط Cereblon لـ Pomalidomide.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2229037-04-9
Sample solution is provided at 25 µL, 10mM.
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Selective anaplastic lymphoma kinase (ALK) degrader (DC50 values are 10 and 180 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide , conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Exhibits higher selectivity for ALK over Aurora A kinase compared with TL 13 -112 (Cat.No. 6745). Maximum degradation is exhibited at 16 h. Negative control TL 13-22 also available.
Powell et al (2018) Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 61 4249 PMID:29660984
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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