TRPV4 agonist-1 free base |
| رقم الكتالوجGC63244 |
إن القاعدة الحرة TRPV4 agonist-1 عبارة عن ناهض لمستقبلات فانيلويد محتملة عابرة 4 (TRPV4) مع EC50 من 60 نانومتر في اختبار hTRPV4 Ca2 +
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Cas No.: 2314467-59-7
Sample solution is provided at 25 µL, 10mM.
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TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].
TRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels[1].
[1]. Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Jan 28.
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