TRPV4 agonist-1 free base |
| Catalog No.GC63244 |
TRPV4 작용제-1 유리 염기는 hTRPV4 Ca2+ 분석에서 EC50이 60nM인 일시적 수용체 전위 바닐로이드 4(TRPV4) 작용제입니다.
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Cas No.: 2314467-59-7
Sample solution is provided at 25 µL, 10mM.
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TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].
TRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels[1].
[1]. Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Jan 28.
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