الصفحة الرئيسية>>Signaling Pathways>> Immunology/Inflammation>> Innate Immunity>>TSI-01

TSI-01

رقم الكتالوجGC41638

عامل تفعيل الصفائح (PAF) هو وسيط فسفوليبيدي يحفز التهابات ويتم تخليقه بشكل سريع من قبل محول لاستيل lyso-PAF (lyso-PAFAT) استجابةً للاستثارة الخارجية.

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TSI-01 التركيب الكيميائي

Cas No.: 704878-75-1

الحجم السعر المخزون الكميّة
1mg
67٫00
متوفر
5mg
302٫00
متوفر
10mg
535٫00
متوفر
25mg
1170٫00
متوفر

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مراجعات العميل

بناء على آراء العملاء.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 µM for human LPCAT2 and LPCAT1, respectively). At 60 µM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.

مراجعات

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