TSI-01 |
| カタログ番号GC41638 |
血小板活性化因子（PAF）は、細胞外刺激に応答してリソ-PAFアセチルトランスフェラーゼ（リソ-PAFAT）によって迅速に合成される炎症性のホスホリピッド中間体です。
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Cas No.: 704878-75-1
Sample solution is provided at 25 µL, 10mM.
Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 µM for human LPCAT2 and LPCAT1, respectively). At 60 µM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.
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