ZK824190 hydrochloride |
| رقم الكتالوجGC64686 |
هيدروكلوريد ZK824190 هو مثبط منشط البلازمينوجين (uPA) المتوفر عن طريق الفم والانتقائي كعلاج محتمل لمرض التصلب المتعدد
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2629177-12-2
Sample solution is provided at 25 µL, 10mM.
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ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively[1].
ZK824190 (2 mg/kg; PO; Rats with EAE model) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h)[1].
[1]. Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375.
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