ZK824190 hydrochloride |
| Catalog No.GC64686 |
ZK824190 염산염은 다발성 경화증에 대한 잠재적 치료제로서 경구로 이용 가능한 선택적 유로키나제 플라스미노겐 활성화제(uPA) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2629177-12-2
Sample solution is provided at 25 µL, 10mM.
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ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively[1].
ZK824190 (2 mg/kg; PO; Rats with EAE model) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h)[1].
[1]. Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375.
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