ZK824190 hydrochloride |
| カタログ番号GC64686 |
ZK824190 塩酸塩は、多発性硬化症の潜在的な治療法として、経口で利用できる選択的なウロキナーゼ プラスミノーゲン活性化因子 (uPA) 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2629177-12-2
Sample solution is provided at 25 µL, 10mM.
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ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively[1].
ZK824190 (2 mg/kg; PO; Rats with EAE model) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h)[1].
[1]. Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375.
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