5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate (Synonyms: CDFDA) |
| Catalog No.GC49339 |
Le diacétate de 5(6)-carboxy-′,7′-dichlorofluorescéine est un indicateur fluorescent à pénétration cellulaire.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 127770-45-0
Sample solution is provided at 25 µL, 10mM.
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5(6)-Carboxy-2’,7’-dichlorofluorescein diacetate is an oxidant-sensitive and cell-permeable fluorescent probe.1 Base hydrolysis of the ester bonds by intracellular esterases releases the acetate groups and the resulting compound, 5(6)-carboxy-2’,7’,-dichlorofluorescein, is oxidized by reactive oxygen species (ROS) and nitric oxide (NO) and displays excitation/emission maxima of 504 and 530 nm, respectively, which can be quantified as a measure of oxidant production.
1.Hempel, S.L., Buettner, G.R., O’Malley, Y.Q., et al.Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2’,7’-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2’,7’-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123Free Radic. Biol. Med.27(1-2)146-159(1999)
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