Adenosine A1 receptor activator T62 |
| Catalog No.GC38733 |
L'activateur du récepteur de l'adénosine A1 T62 est un activateur allostérique du récepteur de l'adénosine A1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 40312-34-3
Sample solution is provided at 25 µL, 10mM.
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Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3].
Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level[1]. Animal Model: Male SpragueDawley rats (250 g) after paw incision surgery[1]
[1]. Obata H, et al. Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury. Anesthesiology. 2004 May;100(5):1258-62. [2]. Li X, et al. Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism. J Pharmacol Exp Ther. 2003 Jun;305(3):950-5. [3]. Soudijn W, et al. Allosteric modulation of G protein-coupled receptors: perspectives and recent developments. Drug Discov Today. 2004 Sep 1;9(17):752-8.
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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