Amino-PEG11-OH |
| Catalog No.GC67174 |
Amino-PEG11-OH est un lieur PEG ADC non clivable à 11 unités utilisé dans la synthèse de conjugués anticorps-médicament (ADC). Amino-PEG11-OH est également un lieur PROTAC à base de PEG qui peut être utilisé dans la synthèse des PROTAC.
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Cas No.: 15332-94-2
Sample solution is provided at 25 µL, 10mM.
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Amino-PEG11-OH is non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG11-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Synthesis of reduced sensitive azo connection unit and application of azo connection unit in DNA (deoxyribonucleic acid) sequencing. CN103539697A.
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