Amino-PEG2-C2-acid |
| Catalog No.GC63660 |
L'amino-PEG2-C2-acide est un lieur clivable PEG ADC À 3 unités utilisé dans la synthèse de conjugués anticorps-médicament (ADC). L'amino-PEG2-C2-acide est également un lieur PROTAC À base de PEG qui peut être utilisé dans la synthèse des PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 791028-27-8
Sample solution is provided at 25 µL, 10mM.
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Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG2-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof. WO2016197946A1.
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