(Arg)9 acetate (Synonyms: Nona-L-arginine acetate; Peptide R9 acetate) |
| Catalog No.GC66389 |
L'acétate de (Arg)9 (Nona-L-arginine) est un peptide pénétrant dans les cellules (CPP) composé de 9 résidus d'arginine. L'acétate (Arg)9 a une propriété neuroprotectrice, présente une activité neuroprotectrice avec une IC50 de 0,78 μM dans le modèle d'acide glutamique.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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IC50: 0.78 μM (neuroprotection)[1]
(Arg)9 (Nona-L-arginine) acetate is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 acetate has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model[1][2].
(Arg)9 (Nona-L-arginine; 5-10 μM) acetate provides significant neuroprotection in a dose-response manner following glutamic acid exposure (IC50=0.78 μM). Following kainic acid exposure, (Arg)9 acetate is neuroprotective, but less effective than in the glutamic acid model (IC50=0.81 μM). (Arg)9 acetate also shows neuroprotection following in vitro ischemia (IC50=6 μM)[1].
(Arg)9 (Nona-L-arginine; 1 μM/kg (600 μL); i.v.; once, for 30min; male Sprague-Dawley ratspermanent middle cerebral artery stroke model) acetate shows neuroprotective effects and reduces infarct volume[2].
| Animal Model: | Male Sprague-Dawley rats (270 to 320 g) permanent middle cerebral artery stroke model[2] |
| Dosage: | 1 μM/kg (600 μL) |
| Administration: | Intravenous injection; once, over 5 minutes |
| Result: | Reduced significantiy 20% in infarct volume. |
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