AZD 5582 dihydrochloride |
| Catalog No.GC50109 |
Le dichlorhydrate d'AZD 5582 est un antagoniste de l'inhibiteur des protéines d'apoptose (IAP), qui se lie aux domaines BIR3 cIAP1, cIAP2 et XIAP avec des IC50 de 15, 21 et 15 nM, respectivement. AZD5582 induit l'apoptose.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1883545-51-4
Sample solution is provided at 25 µL, 10mM.
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Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.
Hennessy et al (2013) Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J.Med.Chem. 56 9897 PMID:24320998
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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