Irinotecan-d10 (hydrochloride) (Synonyms: Camptothecin 11-d10, CPT 11- d10, Topotecin-d10, U 101440E-d10) |
Catalog No.GC47459 |
Le chlorhydrate d'irinotécan-d10 ((+)-irinotécan-d10) est l'irinotécan marqué au deutérium. L'irinotécan ((+)-irinotécan) est un inhibiteur de la topoisomérase I, empêchant la religation du brin d'ADN en se liant au complexe topoisomérase I-ADN.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 718612-62-5
Sample solution is provided at 25 µL, 10mM.
Irinotecan-d10 is intended for use as an internal standard for the quantification of irinotecan by GC- or LC-MS. Irinotecan, a derivative of the alkaloid camptothecin , functions as a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I.1,2 Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1.3,4 Formulations containing irinotecan demonstrate broad spectrum antitumor activity against metastatic colorectal cancer, small cell lung cancer, and several other solid tumors and have proven useful in radiation treatment of tumors by sensitizing tissue to radiation damage.1,2
1.Rothenberg, M.L.Topoisomerase I inhibitors: Review and updateAnn. Oncol.8(9)837-855(1997) 2.Dancey, J., and Eisenhauer, E.A.Current perspectives on camptothecins in cancer treatmentBr. J. Cancer74(3)327-338(1996) 3.Mathijssen, R.H.J., van Alphen, R.J., Verweij, J., et al.Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)Clin. Cancer Res.7(8)2182-2194(2001) 4.Ma, M.K., and McLeod, H.L.Lessons learned from the irinotecan metabolic pathwayCurr. Med. Chem.10(1)41-49(2003)
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