2-Fluoroadenine (Synonyms: F-Ade, NSC 27364) |
| Catalog No.GC46545 |
La 2-fluoroadénine est une base purique toxique. La 2-fluoroadénine a une toxicité dans les cellules tumorales non proliférantes et proliférantes. La 2-fluoroadénine peut être utilisée pour la recherche anticancéreuse.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 700-49-2
Sample solution is provided at 25 µL, 10mM.
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2-Fluoroadenine is a heterocyclic building block that has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activity in vitro.1 It is also cytotoxic to CEM human leukemia cells with an IC50 value of 0.15 µM.2
1.Llauger, L., He, H., Kim, J., et al.Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90J. Med. Chem.48(8)2892-2905(2005) 2.Parker, W.B., Allan, P.W., Shaddix, S.C., et al.Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cellsBiochem. Pharmacol.55(10)1673-1681(1998)
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