6β-Naltrexol-d3 (Synonyms: 6β-hydroxy Naltrexone-d3) |
| Catalog No.GC46730 |
A Certified Reference Material
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1435727-11-9
Sample solution is provided at 25 µL, 10mM.
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6β-Naltrexol-d3 is an analytical reference material intended for use as an internal standard for the quantification of 6β-naltrexol by GC- or LC-MS. 6β-Naltrexol is the major metabolite of naltrexone .1 It is a neutral µ-opioid receptor antagonist (Ki = 94 pM).2,3 This product is intended for research and forensic applications.
1.Porter, S.J., Somogyi, A.A., and White, J.M.Kinetics and inhibition of the formation of 6β-naltrexol from naltrexone in human liver cytosolBr. J. Clin. Pharmacol.50(5)465-471(2000) 2.Wang, D., Raehal, K.M., Bilsky, E.J., et al.Inverse agonists and neutral antagonists at μ opioid receptor (MOR): Possible role of basal receptor signaling in narcotic dependenceJ. Neurochem.77(6)1590-1600(2007) 3.Porter, S.J., Somogyi, A.A., and White, J.M.In vivo and in vitro potency studies of 6β-naltrexol, the major human metabolite of naltrexoneAddict. Biol.7(2)219-225(2002)
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