AGN 193109-d7 |
| Catalog No.GC46817 |
AGN 193109-d7 est l'AGN 193109 marqué au deutérium. AGN 193109 est un analogue de rétinoÏde et agit comme un antagoniste spécifique et très efficace des récepteurs de l'acide rétinoÏque (RAR), avec des Kd de 2 nM, 2 nM et 3 nM pour RARα ; , RARβ, et RARγ, respectivement.
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Cas No.: 1216429-25-2
Sample solution is provided at 25 µL, 10mM.
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AGN 193109-d7 is intended for use as an internal standard for the quantification of AGN 193109 by GC- or LC-MS. AGN 193109 is an antagonist of retinoic acid receptors (RARs).1 AGN 193109 decreases expression of cytokeratin K5-8, 13, 14, 16, 17, and 19 genes, markers of retinoid action in ECE16-1 cells, when co-administered with TTNPB but not when used alone. In vivo, AGN 193109 induces cleft palate or frontonasal dysplasia and eye malformations in fetuses of pregnant mice following a single oral dose of 1 mg/kg.2
1.Agarwal, C., Chandraratna, A.S., Johnson, A.L., et al.AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cellsJ. Biol. Chem.271(21)12209-12212(1996) 2.Kochhar, D.M., Jiang, H., Penner, J.D., et al.The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental eventsInt. J. Dev. Biol.42(4)601-608(1998)
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