Bobcat 339 (Synonyms: BC339) |
| Catalog No.GC46935 |
Bobcat 339 est un inhibiteur puissant et sélectif à base de cytosine de l'enzyme TET, avec des IC50 de 33 μM et 73 μM pour TET1 et TET2, respectivement. Bobcat 339 est utile dans le domaine de l'épigénétique et sert de point de départ pour de nouvelles thérapies qui ciblent la méthylation de l'ADN et la transcription des gènes.
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Cas No.: 2280037-51-4
Sample solution is provided at 25 µL, 10mM.
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Bobcat 339 is an inhibitor of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and TET2 (IC50s = 33 and 73 µM, respectively).1 It is selective for TET1 and TET2 over DNA methyltransferase 3a (DNMT3a) at 500 µM. Bobcat 339 (10 µM) reduces DNA 5-hydroxymethylcytosine (5-hmC) levels in HT22 hippocampal neurons.
1.Chua, G.N.L., Wassarman, K.L., Sun, H., et al.Cytosine-based TET enzyme inhibitorsACS Med. Chem. Lett.10(2)180-185(2019)
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