Dextrorphan-d3 (tartrate) (Synonyms: d-3-hydroxy-N-Methylmorphinan tartrate-d3)

Dextrorphan-d₃ (tartrate) is intended for use as an internal standard for the quantification of dextrorphan (tartrate) by GC- or LC-MS. Dextrorphan is categorized as an arylcyclohexylamine and is a metabolite of dextromethorphan (hydrobromide hydrate) , an antitussive found in cough medicines. Dextrorphan, while also having antitussive activity, is psychoactive, leading to the abuse of cough medicines containing the parent compound.^1,2 Dextrorphan antagonizes NMDA and µ-opioid receptors (K_is = 54 and 420 nM, respectively) and inhibits norepinephrine and serotonin transporters (K_is = 340 and 401 nM, respectively).^3,4,5 This product is intended for research and forensic applications.

1.Shin, E.J., Lee, P.H., Kim, H.J., et al.Neuropsychotoxicity of abused drugs: Potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effectsJournal of Pharmacological Sciences106(1)22-27(2008) 2.Chomchai, C., and Manaboriboon, B.Stimulant methamphetamine and dextromethorphan use among Thai adolescents: implications for health of women and childrenJ.Med.Toxicol.8(3)291-294(2012) 3.LePage, K.T., Ishmael, J.E., Low, C.M., et al.Differential binding properties of [3H]dextrorphan and [3H]MK-801 in heterologously expressed NMDA receptorsNeuropharmacology49(1)1-16(2005) 4.Kaczor, A.A., Kijkowska-Murak, U.A., and Matosiuk, S.Theoretical studies on the structure and symmetry of the transmembrane region of glutamatergic GluR5 receptorJournal of Medicinal Chemistry51(13)3765-3776(2008) 5.Codd, E.E., Shank, R.P., Schupsky, J.J., et al.Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: Structural determinants and role in antinociceptionJ. Pharmacol. Exp. Ther.274(3)1263-1270(1995)