Docetaxel-d9 (Synonyms: DTX-d9, Taxotel-d9) |
| Catalog No.GC47250 |
Le docétaxel-d9 (RP-56976-d9) est le docétaxel marqué au deutérium. Le docétaxel (RP-56976) est un inhibiteur de la dépolymérisation des microtubules, avec une IC50 de 0,2μM. Le docétaxel atténue les effets de l'expression des gènes bcl-2 et bcl-xL. Le docétaxel arrête le cycle cellulaire À G2/M et conduit À l'apoptose cellulaire. Le docétaxel a une activité anticancéreuse.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 940867-25-4
Sample solution is provided at 25 µL, 10mM.
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Docetaxel-d9 is intended for use as an internal standard for the quantification of docetaxel by GC- or LC-MS. Docetaxel is a semisynthetic analog of paclitaxel that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM).1 It has proven more effective than taxol in preventing the proliferation of cancer cells.1,2 Docetaxel has potential applications in breast cancer and hormone-refractory prostate cancer.3,4
1.Bissery, M.C., Guenard, D., Gueritte-Voegelein, F., et al.Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogueCancer Research514845-4852(1991) 2.Pazdur, R., Kudelka, A.P., Kavanagh, J.J., et al.The taxoids: Paclitaxel (Taxolr) and docetaxel (Taxoterer)Cancer Treatment Reviews19351-386(1993) 3.Mahon, K.L., Henshall, S.M., Sutherland, R.L., et al.Pathways of chemotherapy resistance in castration-resistant prostate cancerEndocrine-Related Cancer18R103-R123(2011) 4.Yao, X., Hosenpud, J., Chitambar, C.R., et al.A phase II study of concurrent docetaxel, epirubicin and cyclophospha-mide as a neoadjuvant chemotherapy regimen in patients with locally advanced breast cancerJournal of Cancer3145-151(2012)
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