Eicosapentaenoyl Ethanolamide-d4 (Synonyms: EPEAd4)

Eicosapentaenoyl ethanolamide (EPEA)-d₄ contains four deuterium atoms at the 1, 1', 2, and 2' positions. It is intended for use as an internal standard for the quantification of EPEA by GC- or LC-mass spectrometry. Eicosapentaenoyl Ethanolamide (EPEA) is an N-acylethanolamide that inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes.¹ Produced endogenously from eicosapentaenoic acid, EPEA serves as a metabolic signal that couples nutrient availability with growth and lifespan. EPEA also has anti-inflammatory properties, suppressing the expression of IL-6 and MCP-1 in 3T3-L1 adipocytes in response to lipopolysaccharide.²

1.Lucanic, M., Held, J.M., Vantipalli, M.C., et al.N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegansNature473(7346)226-229(2011) 2.Balvers, M.G., Verhoeckx, K.C., Plastina, P., et al.Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory propertiesBiochimica et Biophysica Acta1801(10)1107-1114(2010)