Menaquinone 4-d7 (Synonyms: MK-4-d7, Vitamin K2(20)-d7) |
Catalog No.GC47619 |
La ménaquinone 4-d7 (vitamine K2(MK-4)-d7) est le deutérium marqué Menaquinone-4. La ménaquinone-4 est une vitamine K, utilisée comme agent hémostatique et également comme traitement d'appoint contre la douleur de l'ostéoporose.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1233937-25-1
Sample solution is provided at 25 µL, 10mM.
Menaquinone 4-d7 (MK-4-d7) is intended for use as an internal standard for the quantification of MK-4 by GC- or LC-MS. MK-4 is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units in the side chain.1 It is formed primarily via conversion of vitamin K1 in vivo and accumulates in various tissues, including the brain.2,3 MK-4 halts the cell cycle at the G1 phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner.4 It also inhibits IκB kinase (IKK) activity, IκBα phosphorylation, and the transcriptional activity of NF-κB. Vitamin K2 may have a role in bone metabolism.1
1.Plaza, S.M., and Lamson, D.W.Vitamin K2 in bone metabolism and osteoporosisAltern. Med. Rev.10(1)24-35(2005) 2.Shearer, M.J., and Newman, P.Metabolism and cell biology of vitamin KThromb. Haemost.100(4)530-547(2008) 3.Okano, T., Shimomura, Y., Yamane, M., et al.Conversion of phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) in mice: Two possible routes for menaquinone-4 accumulation in cerebra of miceJ. Biol. Chem.283(17)11270-11279(2008) 4.Ozaki, I., Zhang, H., Mizuta, T., et al.Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor κB activationClin. Cancer Res.13(7)2236-2245(2007)
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