2-O-methyl PAF C-18 (hydrate) (Synonyms: Edelfosine, ET-18-OCH3, 1Ooctadecyl2Omethylsnglyceryl3phosphorylcholine)

Name: 2-O-methyl PAF C-18 (hydrate)
Brand: GlpBio
SKU: GC48450
Availability: InStock
Rating: 5 (18 reviews)

Catalog No.GC48450

A synthetic PAF analog

Products are for research use only. Not for human use. We do not sell to patients.

2-O-methyl PAF C-18 (hydrate) Chemical Structure

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5mg	72,00 $US	En stock
10mg	137,00 $US	En stock
50mg	576,00 $US	En stock
100mg	977,00 $US	En stock

Tel：(909) 407-4943 Email: sales@glpbio.com

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Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

Nature
618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

View current batch:

Purity: >98.00%

2-O-methyl-PAF C-18 is a synthetic PAF analog which contains a methyl group, attached by an ether linkage, at the sn-2 position. It has been shown to mediate a number of biological responses including decreasing plasma membrane fluidity and inhibiting tumor cell invasiveness in embryonic chick heart.¹ In rat astrocytes, 2-O-methyl PAF C-18 causes the release of large quantities of nitric oxide by a pathway involving activation of nitric oxide synthase.²

1.van Blitterswijk, W.J., Hilkmann, H., and Storme, G.A.Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasionLipids22(11)820-823(1987) 2.Cardile, V., Jiang, X., Renis, M., et al.Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero-3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytesBrain Research715(1-2)98-103(1996)

Cas No.		SDF
Synonymes	Edelfosine, ET-18-OCH3, 1Ooctadecyl2Omethylsnglyceryl3phosphorylcholine
Canonical SMILES	CCCCCCCCCCCCCCCCCCOC[C@@H](OC)COP(OCC[N+](C)(C)C)([O-])=O.O
Formula	C27H58NO6P•XH2O	M.Wt	523.7
Solubility	PBS pH 7.2: >4.5 mg/ml (from Lyso-PAF C-18	Storage	-20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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		1 mg	5 mg	10 mg
	1 mM	1.9095 mL	9.5475 mL	19.0949 mL
	5 mM	0.3819 mL	1.9095 mL	3.819 mL
	10 mM	0.1909 mL	0.9547 mL	1.9095 mL

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for 2-O-methyl PAF C-18 (hydrate)

Average Rating: 5 ★★★★★ (Based on Reviews and 18 reference(s) in Google Scholar.)

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2-O-methyl PAF C-18 (hydrate) (Synonyms: Edelfosine, ET-18-OCH3, 1Ooctadecyl2Omethylsnglyceryl3phosphorylcholine)

Avis des clients

GlpBio Citations

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GlpBio Products Cited In Reputable Papers

Product Documents

Quality Control & SDS

Complete Stock Solution Preparation Table

Molarity Calculator

Dilution Calculator

In vivo Formulation Calculator (Clear solution)

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