Avrainvillamide (Synonyms: CJ-17,665) |
| Catalog No.GC48511 |
Avrainvillamide ((+)-Avrainvillamide) est un alcaloÏde naturel aux effets antiprolifératifs, se lie au chaperon nucléaire nucléophosmine, une protéine oncogène proposée qui est surexprimée dans de nombreuses tumeurs humaines différentes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 269741-97-1
Sample solution is provided at 25 µL, 10mM.
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Avrainvillamide is a fungal metabolite and monomeric form of stephacidin B that has been found in A. ochraceus.1,2 It is active against S. aureus, S. pyogenes, and E. faecalis (MICs = 12.5, 12.5, and 25 µg/ml, respectively).2 Avrainvillamide inhibits the growth of LNCaP, BT-549, T47D, and MALME-3M cancer cells with GI50 values of 0.24, 0.62, 0.21, and 0.41 µM, respectively.1
1.Wulff, J.E., Herzon, S.B., Siegrist, R., et al.Evidence for the rapid conversion of stephacidin B into the electrophilic monomer avrainvillamide in cell cultureJ. Am. Chem. Soc.129(16)4898-4899(2007) 2.Sugie, Y., Hirai, H., Inagaki, T., et al.A new antibiotic CJ-17,665 from Aspergillus ochraceusJ. Antibiot.54(11)911-916(2001)
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