Phentermine-d5 (hydrochloride) (CRM)

Phentermine-d₅ (CRM) is intended for use as an internal standard for the quantification of phentermine by GC- or LC-mass spectrometry. Phentermine is an α-methylated amphetamine that activates trace amine associated receptor 1 (TAAR1, EC₅₀ = 5.47 µM).¹ It potently stimulates the release of norepinephrine (IC₅₀ = 39.4 nM), with less effect on the release of dopamine and serotonin (IC₅₀s = 262 and 3,511 nM, respectively).² Primarily through these actions, phentermine suppresses appetite and augments fat metabolism, supporting usefulness in ameliorating obesity.^3,4

1.Lewin, A.H., Nacarro, H.A., and Mascarella, S.W.Structure-activity correlations for β-phenethylamines at human trace amine receptor 1Bioorganic & Medicinal Chemistry16(15)7415-7423(2008) 2.Rothman, R.B., Baumann, M.H., Dersch, C.M., et al.Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotoninScience39(1)32-41(2001) 3.Li, Z., Maglione, M., Tu, W., et al.Meta-analysis: Pharmacologic treatment of obesityAnnals of Internal Medicine142532-546(2005) 4.Manning, S., Pucci, A., and Finer, N.Pharmacotherapy for obesity: Novel agents and paradigmsTher.Adv.Chronic Dis.5(3)135-148(2014)