BAY-899 |
| Catalog No.GC61746 |
BAY-899 est un antagoniste du récepteur de l'hormone lutéinisante (LH-R) actif et sélectif par voie orale avec des IC50 de 185 nM et 46 nM pour hLH (LH humaine) et rLH (LH de rat), respectivement.
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Cas No.: 2471967-92-5
Sample solution is provided at 25 µL, 10mM.
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BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levels[1].
BAY-899 (oral; 12.5 mg/kg/day; for 8 days) shows an efficiency to reduce serum estradiol levels in intact female rats[1]. BAY-899 (iv of 0.5 mg/kg or po of 2 mg/kg) has a t1/2 of 11 hours and 12 hours for iv and po. And the Cmax is 0.97 kg/L and 0.24 kg/L for iv and po[1]. Animal Model: Intact female rats[1]
[1]. Wortmann L, et al. Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels In Vivo. J Med Chem. 2019 Oct 31.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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